Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus

The nuclear receptor corepressor Hairless (HR) interacts with nuclear receptors and controls expression of specific target genes involved in hair morphogenesis and hair follicle cycling. Patients with HR gene mutations exhibit atrichia, and in rare cases, immunodeficiency. Pigs with HR gene mutation...

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Bibliographic Details
Published in:Exp Anim
Main Authors: Gao, Qing-Shan, Xuan, Mei-Fu, Luo, Zhao-Bo, Paek, Hyo-Jin, Kang, Jin-Dan, Yin, Xi-Jun
Format: Artigo
Language:Inglês
Published: Japanese Association for Laboratory Animal Science 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842791/
https://ncbi.nlm.nih.gov/pubmed/31308290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.19-0018
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