Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT or PDGFRA receptor tyrosine kinases. Chromosome 22q deletions are well-recognized frequent abnormalities in GISTs, occurring in ∼50% of GISTs. These deletions are thought to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pang, Yuzhi, Xie, Feifei, Cao, Hui, Wang, Chunmeng, Zhu, Meijun, Liu, Xiaoxiao, Lu, Xiaojing, Huang, Tao, Shen, Yanying, Li, Ke, Jia, Xiaona, Li, Zhang, Zheng, Xufen, Wang, Simin, He, Yi, Wang, Linhui, Fletcher, Jonathan A., Wang, Yuexiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842588/
https://ncbi.nlm.nih.gov/pubmed/31636198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914542116
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