In vivo immunogenicity assessment and vaccine efficacy evaluation of a chimeric tandem repeat of epitopic region of OMP31 antigen fused to interleukin 2 (IL-2) against Brucella melitensis in BALB/c mice

BACKGROUND: Designing a potent recombinant vaccine, using the appropriate subunits with the greatest effect on stimulating the immune system, especially in the case of intracellular pathogens such as gram negative Brucella Melitensis bacteria, is of great importance. In this study, three repeats of...

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Pubblicato in:BMC Vet Res
Autori principali: Nazifi, Narges, Tahmoorespur, Mojtaba, Sekhavati, Mohammad Hadi, Haghparast, Alireza, Behroozikhah, Ali Mohammad
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842255/
https://ncbi.nlm.nih.gov/pubmed/31703683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-019-2074-7
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