ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2

The bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 are essential for expression of hepcidin, a key iron regulatory hormone. In mice, hepatocyte-specific Alk2 deficiency leads to moderate iron overload with periportal liver iron accumulation, while hepatocyte-specific Alk3 deficiency...

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Publicat a:Free Radic Biol Med
Autors principals: Traeger, Lisa, Gallitz, Inka, Sekhri, Rohit, Bäumer, Nicole, Kuhlmann, Tanja, Kemming, Claudia, Holtkamp, Michael, Müller, Jennifer-Christin, Karst, Uwe, Canonne-Hergaux, Francois, Muckenthaler, Martina U., Bloch, Donald B., Olschewski, Andrea, Bartnikas, Thomas B., Steinbicker, Andrea U.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842210/
https://ncbi.nlm.nih.gov/pubmed/30227271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.09.021
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