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Insights on current and novel antipsychotic mechanisms from the MAM model of schizophrenia
Current antipsychotic drugs (APDs) act on D(2) receptors, and preclinical studies demonstrate that repeated D(2) antagonist administration downregulates spontaneously active DA neurons by producing overexcitation-induced inactivation of firing (depolarization block). Animal models of schizophrenia b...
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| Publicado no: | Neuropharmacology |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6842083/ https://ncbi.nlm.nih.gov/pubmed/31077730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.05.009 |
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