Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros regulates gene expression and cellular proliferation in T-ALL are unknown. Re-introduction of Ikaros into Ikaros-null T-ALL cells resulted in...

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Bibliografske podrobnosti
izdano v:Leukemia
Main Authors: Ding, Yali, Zhang, Bo, Payne, Jonathon L., Song, Chunhua, Ge, Zheng, Gowda, Chandrika, Iyer, Soumya, Dhanyamraju, Pavan K., Dorsam, Glenn, Reeves, Mark E., Desai, Dhimant, Huang, Suming, Payne, Kimberly J., Yue, Feng, Dovat, Sinisa
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842075/
https://ncbi.nlm.nih.gov/pubmed/31073152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0474-0
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