Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

OBJECTIVE: Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile...

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書誌詳細
出版年:Gut
主要な著者: Mullish, Benjamin H, McDonald, Julie A K, Pechlivanis, Alexandros, Allegretti, Jessica R, Kao, Dina, Barker, Grace F, Kapila, Diya, Petrof, Elaine O, Joyce, Susan A, Gahan, Cormac G M, Glegola-Madejska, Izabela, Williams, Horace R T, Holmes, Elaine, Clarke, Thomas B, Thursz, Mark R, Marchesi, Julian R
フォーマット: Artigo
言語:Inglês
出版事項: BMJ Publishing Group 2019
主題:
Gut Microbiota
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839797/
https://ncbi.nlm.nih.gov/pubmed/30816855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317842
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