Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

OBJECTIVE: Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Mullish, Benjamin H, McDonald, Julie A K, Pechlivanis, Alexandros, Allegretti, Jessica R, Kao, Dina, Barker, Grace F, Kapila, Diya, Petrof, Elaine O, Joyce, Susan A, Gahan, Cormac G M, Glegola-Madejska, Izabela, Williams, Horace R T, Holmes, Elaine, Clarke, Thomas B, Thursz, Mark R, Marchesi, Julian R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Gut Microbiota
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839797/
https://ncbi.nlm.nih.gov/pubmed/30816855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317842
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