Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

OBJECTIVE: Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Gut
Prif Awduron: Mullish, Benjamin H, McDonald, Julie A K, Pechlivanis, Alexandros, Allegretti, Jessica R, Kao, Dina, Barker, Grace F, Kapila, Diya, Petrof, Elaine O, Joyce, Susan A, Gahan, Cormac G M, Glegola-Madejska, Izabela, Williams, Horace R T, Holmes, Elaine, Clarke, Thomas B, Thursz, Mark R, Marchesi, Julian R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2019
Pynciau:
Gut Microbiota
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839797/
https://ncbi.nlm.nih.gov/pubmed/30816855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317842
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