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Periodic Oxaliplatin Administration in Synergy with PER2‐Mediated PCNA Transcription Repression Promotes Chronochemotherapeutic Efficacy of OSCC

Developing chemotherapeutic resistance affects clinical outcomes of oxaliplatin treatment on various types of cancer. Thus, it is imperative to explore alternative therapeutic strategies to improve the efficacy of oxaliplatin. Here, it is shown that circadian regulator period 2 (PER2) can potentiate...

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Detalles Bibliográficos
Publicado en:Adv Sci (Weinh)
Main Authors: Tang, Qingming, Xie, Mengru, Yu, Shaoling, Zhou, Xin, Xie, Yanling, Chen, Guangjin, Guo, Fengyuan, Chen, Lili
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839751/
https://ncbi.nlm.nih.gov/pubmed/31728273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201900667
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