Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions

BACKGROUND: Type 2 diabetes (T2DM) increases the risk for Alzheimer’s disease (AD) but not for AD neuropathology. The association between T2DM and AD is assumed to be mediated through vascular mechanisms. However, insulin resistance (IR), the hallmark of T2DM, has been shown to associate with AD neu...

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Pubblicato in:J Alzheimers Dis
Autori principali: Toppala, Sini, Ekblad, Laura L., Lötjönen, Jyrki, Helin, Semi, Hurme, Saija, Johansson, Jarkko, Jula, Antti, Karrasch, Mira, Koikkalainen, Juha, Laine, Hanna, Parkkola, Riitta, Viitanen, Matti, Rinne, Juha O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: IOS Press 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839606/
https://ncbi.nlm.nih.gov/pubmed/31561373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190691
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