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Is combining an anticholinergic with a cholinesterase inhibitor a good strategy for high-level CNS cholinesterase inhibition?
The currently approved cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) produce gastrointestinal toxicity which limits dosing to that which produces only about 25% to 35% CNS cholinesterase inhibition in Alzheimer’s patients undergoing treatment, below the minimum therapeutic tar...
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| Veröffentlicht in: | J Alzheimers Dis |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6839449/ https://ncbi.nlm.nih.gov/pubmed/31476160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190626 |
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