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Is combining an anticholinergic with a cholinesterase inhibitor a good strategy for high-level CNS cholinesterase inhibition?

The currently approved cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) produce gastrointestinal toxicity which limits dosing to that which produces only about 25% to 35% CNS cholinesterase inhibition in Alzheimer’s patients undergoing treatment, below the minimum therapeutic tar...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Autor principal: Moss, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839449/
https://ncbi.nlm.nih.gov/pubmed/31476160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190626
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