Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains

During metastasis, cancer cells navigate through a spatially heterogeneous extracellular matrix (ECM). Physical properties of ECM, including the degree of confinement, influence cell migration behavior. Here, utilizing in vitro three-dimensional collagen microtracks, we demonstrate that cell-ECM int...

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Pubblicato in:Biophys J
Autori principali: Mosier, Jenna A., Rahman-Zaman, Aniqua, Zanotelli, Matthew R., VanderBurgh, Jacob A., Bordeleau, Francois, Hoffman, Brenton D., Reinhart-King, Cynthia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838744/
https://ncbi.nlm.nih.gov/pubmed/31623884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.09.024
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