Vinculin regulates directionality and cell polarity in two- and three-dimensional matrix and three-dimensional microtrack migration

During metastasis, cells can use proteolytic activity to form tube-like “microtracks” within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro three-dimens...

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發表在:Mol Biol Cell
Main Authors: Rahman, Aniqua, Carey, Shawn P., Kraning-Rush, Casey M., Goldblatt, Zachary E., Bordeleau, Francois, Lampi, Marsha C., Lin, Deanna Y., García, Andrés J., Reinhart-King, Cynthia A.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850031/
https://ncbi.nlm.nih.gov/pubmed/26960796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0432
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