Vinculin regulates directionality and cell polarity in two- and three-dimensional matrix and three-dimensional microtrack migration

During metastasis, cells can use proteolytic activity to form tube-like “microtracks” within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro three-dimens...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Rahman, Aniqua, Carey, Shawn P., Kraning-Rush, Casey M., Goldblatt, Zachary E., Bordeleau, Francois, Lampi, Marsha C., Lin, Deanna Y., García, Andrés J., Reinhart-King, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850031/
https://ncbi.nlm.nih.gov/pubmed/26960796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0432
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