High-Throughput Assessment of Kinome-wide Activation States

Aberrant kinase activity has been linked to a variety of disorders; however, methods to probe kinase activation states in cells have been lacking. Until now, kinase activity has mainly been deduced from either protein expression or substrate phosphorylation levels. Here, we describe a strategy to di...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Schmidlin, Thierry, Debets, Donna O., van Gelder, Charlotte A.G.H., Stecker, Kelly E., Rontogianni, Stamatia, van den Eshof, Bart L., Kemper, Kristel, Lips, Esther H., van den Biggelaar, Maartje, Peeper, Daniel S., Heck, Albert J.R., Altelaar, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838672/
https://ncbi.nlm.nih.gov/pubmed/31521607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.08.005
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