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Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination
Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin disease, suffer from low efficiencies and safety concerns that complicate implementation in clinical settings. We present a strategy for efficient and prec...
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| Publicado no: | Mol Ther Nucleic Acids |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6838546/ https://ncbi.nlm.nih.gov/pubmed/31670199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.09.011 |
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