G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome

DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes. It is generally believed that ionizing radiation (IR) induces DNA strand-breaks in a random manner. Here, we show that regions of...

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Vydáno v:iScience
Hlavní autoři: Kumari, Nitu, Vartak, Supriya V., Dahal, Sumedha, Kumari, Susmita, Desai, Sagar S., Gopalakrishnan, Vidya, Choudhary, Bibha, Raghavan, Sathees C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838516/
https://ncbi.nlm.nih.gov/pubmed/31678912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.033
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