Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease

BACKGROUND: Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS: We have now investi...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Podlesniy, Petar, Puigròs, Margalida, Serra, Núria, Fernández-Santiago, Rubén, Ezquerra, Mario, Tolosa, Eduardo, Trullas, Ramon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838390/
https://ncbi.nlm.nih.gov/pubmed/31631040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.015
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