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Genetic Ablation of Calcium-independent Phospholipase A(2)γ Exacerbates Glomerular Injury in Adriamycin Nephrosis in Mice

Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) in mice results in marked damage of mitochondria and enhanced autophagy in glomerular visceral epithelial cells (GECs) or podocytes. The present study addresses the role of iPLA(2)γ in glomerular injury. In adriamycin nephrosis,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Elimam, Hanan, Papillon, Joan, Guillemette, Julie, Navarro-Betancourt, José R., Cybulsky, Andrey V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838178/
https://ncbi.nlm.nih.gov/pubmed/31700134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52834-x
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