Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomerulonephritis but not for liver pathology in mice expressing the ubiquitin-binding–defective ABIN1[D485N] mutant. The blood and organs of ABIN1[D485N] mice have exceptionally high numbers of patrolling...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Principais autores: Nanda, Sambit Kumar, Petrova, Tsvetana, Marchesi, Francesco, Gierlinski, Marek, Razsolkov, Momchil, Lee, Katherine L, Wright, Stephen W, Rao, Vikram R, Cohen, Philip, Arthur, J Simon C
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6836709/
https://ncbi.nlm.nih.gov/pubmed/31694920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900533
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