Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

BACKGROUND: Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available. METHODS: Herein...

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Vydáno v:J Biomed Sci
Hlavní autoři: Wong, Henry Sung-Ching, Lin, Ying-Ju, Lu, Hsing-Fang, Liao, Wen-Ling, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Chang, Wei-Chiao, Tsai, Fuu-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6836357/
https://ncbi.nlm.nih.gov/pubmed/31699087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0581-2
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