Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy

This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nu...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Ko, Toshiyuki, Fujita, Kanna, Nomura, Seitaro, Uemura, Yukari, Yamada, Shintaro, Tobita, Takashige, Katoh, Manami, Satoh, Masahiro, Ito, Masamichi, Domoto, Yukako, Hosoya, Yumiko, Amiya, Eisuke, Hatano, Masaru, Morita, Hiroyuki, Fukayama, Masashi, Aburatani, Hiroyuki, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834953/
https://ncbi.nlm.nih.gov/pubmed/31709317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.05.010
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