Glutamate/metabotropic glutamate receptor-5 signaling in hepatic stellate cells drives endocannabinoid-mediated alcoholic steatosis

Activation of hepatocyte cannabinoid receptor-1 (CB(1)R) by hepatic stellate cell (HSC)-derived 2-arachidonoylglycerol (2-AG) drives de novo lipogenesis in alcoholic liver disease (ALD). How alcohol stimulates 2-AG production in HSCs is unknown. Here, we report that chronic alcohol consumption induc...

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Udgivet i:Cell Metab
Main Authors: Choi, Won-Mook, Kim, Hee-Hoon, Kim, Myung-Ho, Cinar, Resat, Yi, Hyon-Seung, Eun, Hyuk Soo, Kim, Seok-Hwan, Choi, Young Jae, Lee, Young-Sun, Kim, So Yeon, Seo, Wonhyo, Lee, Jun-Hee, Shim, Young-Ri, Kim, Ye Eun, Yang, Keungmo, Ryu, Tom, Hwang, Jung Hwan, Lee, Chul-Ho, Choi, Hueng-Sik, Gao, Bin, Kim, Won, Kim, Sang Kyum, Kunos, George, Jeong, Won-Il
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834910/
https://ncbi.nlm.nih.gov/pubmed/31474565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.001
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