Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury

INTRODUCTION: Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes expression. METHODS: Profile of sphingol...

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Bibliografiska uppgifter
I publikationen:Thorax
Huvudupphovsmän: Ebenezer, David L, Berdyshev, Evgeny V, Bronova, Irina A, Liu, Yuru, Tiruppathi, Chinnaswamy, Komarova, Yulia, Benevolenskaya, Elizaveta V, Suryadevara, Vidyani, Ha, Alison W, Harijith, Anantha, tuder, Rubin M, Natarajan, Viswanathan, Fu, Panfeng
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834354/
https://ncbi.nlm.nih.gov/pubmed/30723184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2018-212378
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