Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

BACKGROUND: Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human synovial tissues (ST), and its impact on the pro-inflammatory function of synovia...

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Veröffentlicht in:Immun Ageing
Hauptverfasser: Del Rey, Manuel J., Valín, Álvaro, Usategui, Alicia, Ergueta, Sandra, Martín, Eduardo, Municio, Cristina, Cañete, Juan D., Blanco, Francisco J., Criado, Gabriel, Pablos, José L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833299/
https://ncbi.nlm.nih.gov/pubmed/31708994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12979-019-0169-4
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