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Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiourea and guanidine r...
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| Pubblicato in: | Molecules |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6832952/ https://ncbi.nlm.nih.gov/pubmed/31614780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203676 |
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