Harnessing coumarin-thio(seleno)cyanate conjugates: potent In vivo antiproliferative agents targeting carbonic anhydrases

We synthesised coumarin-based derivatives bearing thio- and selenocyanates to selectively inhibit tumour-associated carbonic anhydrases (CAs) IX and XII and to exert antiproliferative effects on tumour cells. Structural variations included chalcogen atom type (S, Se), substitutions at C-3/C-4, and t...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Silvia Alejandra Meza-Ireta, Laura L. Romero-Hernández, Paloma Begines, Simone Giouvannuzi, Adrián Puerta, Aday González-Bakker, Amador Romero-Franco, Pablo Huertas, Alessio Nocentini, José Luis Vega-Báez, Sara Montiel-Smith, José G. Fernández-Bolaños, Maikel Castellano-Pozo, José M. Padrón, Claudiu T. Supuran, Penélope Merino-Montiel, Óscar López
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2025-12-01
Edice:	Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:	coumarins carbonic anhydrases organoselenium antiproliferative agents C. elegans
On-line přístup:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2578183
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!