Harnessing coumarin-thio(seleno)cyanate conjugates: potent In vivo antiproliferative agents targeting carbonic anhydrases

We synthesised coumarin-based derivatives bearing thio- and selenocyanates to selectively inhibit tumour-associated carbonic anhydrases (CAs) IX and XII and to exert antiproliferative effects on tumour cells. Structural variations included chalcogen atom type (S, Se), substitutions at C-3/C-4, and t...

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Detalhes bibliográficos

Principais autores:	Silvia Alejandra Meza-Ireta, Laura L. Romero-Hernández, Paloma Begines, Simone Giouvannuzi, Adrián Puerta, Aday González-Bakker, Amador Romero-Franco, Pablo Huertas, Alessio Nocentini, José Luis Vega-Báez, Sara Montiel-Smith, José G. Fernández-Bolaños, Maikel Castellano-Pozo, José M. Padrón, Claudiu T. Supuran, Penélope Merino-Montiel, Óscar López
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2025-12-01
Colecção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	coumarins carbonic anhydrases organoselenium antiproliferative agents C. elegans
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2578183
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