The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats

RATIONALE: Pathological amphetamine (AMPH) use is a serious public health concern with no pharmacological treatment options. Protein kinase Cβ (PKCβ) has been implicated in the mechanism of action of AMPH, such that inhibition of PKCβ attenuates AMPH-stimulated dopamine efflux in vivo. With this in...

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Bibliographic Details
Published in:Psychopharmacology (Berl)
Main Authors: Altshuler, Rachel D., Carpenter, Colleen A., Franke, Timothy J., Gnegy, Margaret E., Jutkiewicz, Emily M.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832797/
https://ncbi.nlm.nih.gov/pubmed/31134292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-019-05278-0
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