Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy

Mitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1(−/−)) exhibit high levels of oxygen-derived radicals...

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Publicat a:Redox Biol
Autors principals: Ahn, Bumsoo, Smith, Nataliya, Saunders, Debra, Ranjit, Rojina, Kneis, Parker, Towner, Rheal A., Van Remmen, Holly
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831885/
https://ncbi.nlm.nih.gov/pubmed/31470261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101308
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