Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an increased mortality. Metabolic reprogramming has a critical role in multiple chronic diseases. Lung macrophages expressing the mitochondrial calcium uniporter (MCU) have a critical role in fibrotic repair, but the contribution of M...

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Publicat a:Redox Biol
Autors principals: Gu, Linlin, Larson Casey, Jennifer L., Andrabi, Shaida A., Lee, Jun Hee, Meza-Perez, Selene, Randall, Troy D., Carter, A. Brent
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831865/
https://ncbi.nlm.nih.gov/pubmed/31473487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101307
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