Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

JIP3 and JIP4 (JNK-interacting proteins 3 and 4) are adaptors for cargo recruitment by dynein/dynactin and kinesin1 motors. Both are dimers that are stabilised by two sections of leucine zipper coiled coils. The N-terminal Leucine Zipper I (LZI) belongs to a section that binds dynein-DLIC and kinesi...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Vilela, Fernando, Velours, Christophe, Chenon, Mélanie, Aumont-Nicaise, Magali, Campanacci, Valérie, Thureau, Aurélien, Pylypenko, Olena, Andreani, Jessica, Llinas, Paola, Ménétrey, Julie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831827/
https://ncbi.nlm.nih.gov/pubmed/31690808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52537-3
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