HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

HIV Nef is a central auxiliary protein in HIV infection and pathogenesis. Our results indicate that HDAC6 promotes the aggresome/autophagic degradation of the viral polyprotein Pr55Gag to inhibit HIV-1 production. Nef counteracts this antiviral activity of HDAC6 by inducing its degradation and subse...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Marrero-Hernández, Sara, Márquez-Arce, Daniel, Cabrera-Rodríguez, Romina, Estévez-Herrera, Judith, Pérez-Yanes, Silvia, Barroso-González, Jonathan, Madrid, Ricardo, Machado, José-David, Blanco, Julià, Valenzuela-Fernández, Agustín
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831784/
https://ncbi.nlm.nih.gov/pubmed/31736889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.02437
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