SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function

The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the ubiquitin-rich IKK complex. We previously demonstrated that Optin...

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Vydáno v:Sci Rep
Hlavní autoři: Schwob, Aurélien, Teruel, Elodie, Dubuisson, Louise, Lormières, Florence, Verlhac, Pauline, Abudu, Yakubu Princely, Gauthier, Janelle, Naoumenko, Marie, Cloarec-Ung, Fanny-Meï, Faure, Mathias, Johansen, Terje, Dutartre, Hélène, Mahieux, Renaud, Journo, Chloé
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831704/
https://ncbi.nlm.nih.gov/pubmed/31690813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52408-x
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