Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing

Rationale: Mutations of SLC26A4 that abrogate pendrin, expressed in endolymphatic sac, cochlea and vestibule, are known to cause autosomal recessive sensorineural hearing loss with enlargement of the membranous labyrinth. This is the first study to demonstrate the feasibility of gene therapy for pen...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Theranostics
Hlavní autoři: Kim, Min-A, Kim, Sung Huhn, Ryu, Nari, Ma, Ji-Hyun, Kim, Ye-Ri, Jung, Jinsei, Hsu, Chuan-Jen, Choi, Jae Young, Lee, Kyu-Yup, Wangemann, Philine, Bok, Jinwoong, Kim, Un-Kyung
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831294/
https://ncbi.nlm.nih.gov/pubmed/31695761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.38032
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky