Whole-blood incubation with the Neisseria meningitidis lpxL1 mutant induces less pro-inflammatory cytokines than the wild type, and IL-10 reduces the MyD88-dependent cytokines

Levels of bacterial LPS, pro-inflammatory cytokines and IL-10 are related to the severity of meningococcal septicaemia. Patients infected with a Neisseria meninigitidis lpxL1 mutant (Nm-mutant) with penta-acylated lipid A present with a milder meningococcal disease than those infected with hexa-acyl...

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Библиографические подробности
Опубликовано в: :Innate Immun
Главные авторы: Aass, Hans Christian D, Hellum, Marit, Trøseid, Anne-Marie Siebke, Brandtzaeg, Petter, Berg, Jens Petter, Øvstebø, Reidun, Henriksson, Carola Elisabeth
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2018
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830899/
https://ncbi.nlm.nih.gov/pubmed/29313733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425917749299
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