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GLUCOCORTICOIDS INHIBIT NOTCH TARGET GENE EXPRESSION IN OSTEOBLASTS

Glucocorticoids in excess suppress osteoblast function and cause osteoporosis. We demonstrated that cortisol induces the expression of selected Notch receptors in osteoblasts, revealing a potential mechanism for the skeletal effects of glucocorticoids. However, it remains to be determined whether in...

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Bibliographic Details
Published in:J Cell Biochem
Main Authors: Zanotti, Stefano, Yu, Jungeun, Adhikari, Suyash, Canalis, Ernesto
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830575/
https://ncbi.nlm.nih.gov/pubmed/29575203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26798
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