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Notch Inhibits Osteoblast Differentiation and Causes Osteopenia
Notch receptors are determinants of cell fate decisions. To define the role of Notch in the adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD) under the control of the type I collagen promoter. First-generation transgenics were small and osteopenic. Bone...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2488209/ https://ncbi.nlm.nih.gov/pubmed/18420737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0140 |
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