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Myeloid cell-synthesized coagulation Factor X dampens anti-tumor immunity

Immune evasion in the tumor microenvironment (TME) is a crucial barrier for effective cancer therapy and plasticity of innate immune cells may contribute to failures of targeted immuno-therapies. Here, we show that rivaroxaban, a direct inhibitor of activated coagulation factor X (FX) promotes antit...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Graf, Claudine, Wilgenbus, Petra, Pagel, Sven, Pott, Jennifer, Marini, Federico, Reyda, Sabine, Kitano, Maki, Macher-Göppinger, Stephan, Weiler, Hartmut, Ruf, Wolfram
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830514/
https://ncbi.nlm.nih.gov/pubmed/31541031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw8405
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