Genome-wide promoter DNA Methylation Profiling of Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Exposure to Ginkgo biloba Extract (GBE) in B6C3F1/N Mice

Epigenetic modifications, such as DNA methylation, play an important role in carcinogenesis. In a recent NTP study, chronic exposure of B6C3F1/N mice to Ginkgo biloba extract (GBE) resulted in a high incidence of hepatocellular carcinomas (HCC). Genome-wide promoter methylation profiling on GBE-expo...

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Détails bibliographiques
Publié dans:Arch Toxicol
Auteurs principaux: Kovi, Ramesh C., Bhusari, Sachin, Mav, Deepak, Shah, Ruchir R., Ton, Thai Vu, Hoenerhoff, Mark J., Sills, Robert C., Pandiri, Arun R.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830449/
https://ncbi.nlm.nih.gov/pubmed/31278416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-019-02505-7
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