Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43(fl/fl) and Cx43(Cre-ER(T)/fl) inducible knock-out (Cx43 content: 50%) mice t...

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Pubblicato in:Cells
Autori principali: Valls-Lacalle, Laura, Negre-Pujol, Corall, Rodríguez, Cristina, Varona, Saray, Valera-Cañellas, Antoni, Consegal, Marta, Martínez-González, Jose, Rodríguez-Sinovas, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830333/
https://ncbi.nlm.nih.gov/pubmed/31652649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101299
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