Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43(fl/fl) and Cx43(Cre-ER(T)/fl) inducible knock-out (Cx43 content: 50%) mice t...

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Publicado no:Cells
Main Authors: Valls-Lacalle, Laura, Negre-Pujol, Corall, Rodríguez, Cristina, Varona, Saray, Valera-Cañellas, Antoni, Consegal, Marta, Martínez-González, Jose, Rodríguez-Sinovas, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830333/
https://ncbi.nlm.nih.gov/pubmed/31652649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101299
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