Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa

A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (bacteria, fungi, and protozoa) was shown to p...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Alissa, Siham A., Alghulikah, Hanan A., Alothman, Zeid A., Osman, Sameh M., Del Prete, Sonia, Capasso, Clemente, Nocentini, Alessio, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830296/
https://ncbi.nlm.nih.gov/pubmed/31663383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1681987
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