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WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors

Genotoxic stress triggers a combined action of DNA repair and cell cycle checkpoint pathways. Protein phosphatase 2C delta (referred to as WIP1) is involved in timely inactivation of DNA damage response by suppressing function of p53 and other targets at chromatin. Here we show that WIP1 promotes DN...

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Bibliografski detalji
Izdano u:Cells
Glavni autori: Burdova, Kamila, Storchova, Radka, Palek, Matous, Macurek, Libor
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830099/
https://ncbi.nlm.nih.gov/pubmed/31619012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101258
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