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A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD), an increasingly prevalent and underdiagnosed disease, is postulated to be caused by hepatic fat mediated pathological mechanisms. Mitochondrial dysfunction is proposed to be involved, but it is not known whether this is a pathological driver or a consequenc...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Malik, Afshan N, Simões, Inês C.M., Rosa, Hannah S., Khan, Safa, Karkucinska-Wieckowska, Agnieszka, Wieckowski, Mariusz R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830072/
https://ncbi.nlm.nih.gov/pubmed/31597406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101222
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