Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

BACKGROUND: Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and consequently cell survival, but biological functions...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Bentayeb, Hafidha, Aitamer, Marine, Petit, Barbara, Dubanet, Lydie, Elderwish, Sabria, Désaubry, Laurent, de Gramont, Armand, Raymond, Eric, Olivrie, Agnès, Abraham, Julie, Jauberteau, Marie-Odile, Troutaud, Danielle
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830009/
https://ncbi.nlm.nih.gov/pubmed/31684984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1440-4
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