Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans

Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates. However, Fam20 kinases are conserved in invertebrates lacking bone and enamel, suggesting other ancestral functions. We show that FAMK-1, th...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Gerson-Gurwitz, Adina, Worby, Carolyn A., Lee, Kian-Yong, Khaliullin, Renat, Bouffard, Jeff, Cheerambathur, Dhanya, Oegema, Karen, Cram, Erin J., Dixon, Jack E., Desai, Arshad
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829671/
https://ncbi.nlm.nih.gov/pubmed/31541016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807041
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