Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans

Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates. However, Fam20 kinases are conserved in invertebrates lacking bone and enamel, suggesting other ancestral functions. We show that FAMK-1, th...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Gerson-Gurwitz, Adina, Worby, Carolyn A., Lee, Kian-Yong, Khaliullin, Renat, Bouffard, Jeff, Cheerambathur, Dhanya, Oegema, Karen, Cram, Erin J., Dixon, Jack E., Desai, Arshad
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829671/
https://ncbi.nlm.nih.gov/pubmed/31541016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807041
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