A PINCH-1–Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation

Mechano-environment plays multiple critical roles in the control of mesenchymal stem cell (MSC) fate decision, but the underlying signaling mechanisms remain undefined. We report here a signaling axis consisting of PINCH-1, SMAD specific E3 ubiquitin protein ligase 1 (Smurf1), and bone morphogenetic...

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Udgivet i:J Cell Biol
Main Authors: Guo, Ling, Wang, Rong, Zhang, Kuo, Yuan, Jifan, Wang, Jiaxin, Wang, Xiaoxia, Ma, Jianfei, Wu, Chuanyue
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829670/
https://ncbi.nlm.nih.gov/pubmed/31578224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902022
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