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Kindlin-2 links mechano-environment to proline synthesis and tumor growth
Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes kindlin-2 translocatio...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6381112/ https://ncbi.nlm.nih.gov/pubmed/30783087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08772-3 |
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